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Furthermore, inorganic arsenic (As 3+ and As 5+ ), which can be found at elevated levels in drinking water in certain regions, has been shown to correlate with increased bladder cancer risk due to chronic consumption (Wong et al., 2024)

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Research has demonstrated that GPER activation promotes insulin release via the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway and enhances pancreatic -cell function and survival [73]