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4 Cardiovascular Diseases Aging and metabolic stress are associated with a decline in NAD+ levels, which can lead to mitochondrial dysfunction and increased susceptibility to cardiovascular diseases

Further investigation into its underlying mechanisms revealed that CP ameliorates ALD by modulating GM diversity, reducing the relative abundance of Proteobacteria and Parasutterella while increasing that of Lactobacillus and Akkermansia, restoring intestinal barrier function, elevating the expression levels of intestinal tight-junction proteins, reducing the leakage of harmful substances such as LPS from the gut, and modulating the Nrf2/Kelch-like ECH-associated protein 1 pathway to diminish hepatic oxidative stress damage and inflammatory responses [227]

and 4) To create a highly efficient laboratory to develop and validate technologies needed more broadly in MS

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Balamurugan, V

doi: 10.1007/s10120-014-0351-5 51 Van CutsemEde HaasSKangYKOhtsuATebbuttNCXuJMet al