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However, UBR5-dependent polyubiquitylation was less efficient when co-incubated with wild-type OTUD5 than with C224R OTUD5 (Fig

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Consequently, ectopic overexpression of NPLOC4 reverses CuET-mediated cytotoxicity (Skrott et al., 2017), although the role of VCP in this process remains unknown

Similar content being viewed by others Background Obsessivecompulsive and related disorders (OCRDs) are a group of intractable and chronic mental disorders in which the pathological mechanism is still unclear and in which the therapeutic effect is unsatisfactory [1]