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JCI Insight 9 , e175159 (2024)

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Franke et al., 2003

210212 In high-fat diet-induced MASLD models, resveratrol significantly reduces hepatic lipid droplet area, suppresses SREBP-1c and fatty acid synthase expression, and elevates carnitine palmitoyltransferase 1A levels, thereby decreasing lipid accumulation

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Thus, while a 100 amino acid protein can contain only 2,000 different mutations, 20 100 sequence combinations are possible