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Many of these conditions are age-related in that damage is accrued over time

Ekstedt M, et al

J.VyavahareV

62 In addition to their ability to generate HETEs via a similar process as described above for 5-LOX, 12-LOX and 15-LOX also generate LXs, oxo-ETEs, and dihydroxyeicosatetraenoic acids (diHETEs)