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Statements Author contributions XH: Data curation, Formal Analysis, Writing original draft

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KPV became interesting to researchers because it appears to retain much of the anti-inflammatory activity associated with alpha-MSH while being much smaller

However, the suitability of current in vitro models, including those based on ARPE-19 cells, for accurately recapitulating RPE physiology in the context of diabetes warrants further optimization

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Adherence matters more than speed, and a researcher who completes the full protocol at a slower pace will achieve better long-term results than someone who quits halfway through a faster schedule due to intolerable side effects