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If it turns out that the N-terminal extension is indeed a targeting sequence, this motif is located around the position 60, otherwise it is located around the position 120

Potential Drawbacks and Side Effects to Consider Creatine is widely studied and generally well tolerated, but there are still a few considerations to keep in mind

To optimize assisted reproductive technology (ART) outcomes, protocols should incorporate individual assessments of environmental exposures such as air pollution, endocrine-disrupting chemicals, heavy metals, and occupational hazards while also considering regional environmental risk factors that may influence sperm quality and fertilization potential

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doi:10.1016/j.jconrel.2016.11.025