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The significant accumulation of ROS has the potential to inhibit the proliferation of tumor cells and induce apoptosis or necrosis, which can be attributed to the activation of various pathways, including endoplasmic reticulum stress, mitochondrial dysfunction, P53-mediated apoptosis, ferroptosis, and other mechanisms

10.1016/j.colsurfb.2018.04.007 125 VoroneanuL.SiriopolD.DumeaR.BadarauS.KanbayM.AfsarB.et al (2017)

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Interestingly, a significant striatal hypometabolism has been observed in patients who are pre-symptomatic for HD, using well-established 18F-FDG PET/CT methods 56

Genetic inactivation of components in the necrosis pathway (calpains and cathepsins) can delay worm death, confirming a role for systemic necrosis in starvation-induced organismal death

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