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Although Pck1 expression in Insr P1195L/ +/HFD mice was not significantly different from that in WT/HFD mice, G6pc expression in Insr P1195L/ +/HFD mice was markedly elevated by re-feeding

This age-related decline coincides with increased susceptibility to both neuropathy and neurodegenerative conditions, suggesting a possible protective role for endogenous GHK that diminishes with aging

In the first study, the authors reported the appearance of dying OLs expressing activated caspase 3 which was accompanied by a significant decrease in NogoA-positive mature OLs after 6 days of CPZ feeding at the dose of 0.3%, and they also claimed that apoptotic OLs were present not only in the corpus callosum but also in the cortex 2 days after the start of the CPZ diet, although they did not show the data (Hesse et al., 2010).The second and more recent study showed the loss of CC1-positive OLs in the corpus callosum as early as 2 days after CPZ exposure in the standardized CPZ model (Jhelum et al., 2020)