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Loprinzi Cl, Qin R, Dakhil SR, et al

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Researchers have long suspected that a microorganism may be the true producer of the anti-cancer drug, but its genome has remained elusive due to our inability to culture the bacterium in the laboratory using standard techniques

When the promotion of ferroptosis execution exceeds the cellular defense system, the accumulation of lipid peroxides can induce cell ferroptosis ( Figure 1 Ferroptosis is a form of iron-dependent programmed cell death, and its molecular mechanisms involve multiple signaling pathways

Dsup protein is highly basic (pI=10.55), especially in the C-terminal region, suggesting its potential association with DNA through electrostatic interactions

Conditional knockout of Rest in RTECs ameliorates IRI-induced ferroptosis and AKI-to-CKD transition