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Description

ROS then interacts with lipids in the cell membranes causing cellular death

Stross, C

Reprod Biol Endocrinol 17:19 Codrington AM, Hales BF, Robaire B (2004) Spermiogenic germ cell phasespecific DNA damage following cyclophosphamide exposure

100,101 This is coupled with the upregulation of the cell cycle regulators P16, P21, and P53, leading to cell cycle arrest and diminished proliferative capacity