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In the most recent 2017 position statement, the ADA supports the use of pregabalin and duloxetine to treat NP in patients with diabetes (see Table 4) [28]

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A change in the regulation of Ca 2+ in lymphocytes disrupts the control of metabolism, proliferation, differentiation, secretion of antibodies, cytokines and cytotoxicity, which leads to autoimmune and inflammation diseases (130)

This calculator provides a user friendly tool, allowing the user to compute MISI using the standard method or the modified method, which is recommended when using data with limited temporal information or with unequally spaced sampling intervals, while also standardising both the computational method and units used

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