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Nature Reviews Endocrinol

Brain Pathol 20 (2010): 838844

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467,469 Those toxic lipids can lead to respiratory chain complex inhibition, OXPHOS uncoupling, ROS overproduction, and persistent mPTP opening, resulting in ultimate cell death

These properties position curcumin as a promising candidate for ALS, but further investigation is still warranted to fully elucidate its efficacy and mechanism of action