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doi: 10.1073/pnas.1606324113 139 MinandriF.ImperiF.FrangipaniE.BonchiC.VisaggioD.FacchiniM.et al

Results Biochemical Measurements Serum Levels of (ALT) and (AST) The mean serum ALT level was significantly higher (P 0.05) from the control group

A comprehensive prevention strategy combining lifestyle interventions, pharmacological therapies, and biomarker-driven diagnostics is crucial to reducing obesity-related cancer burden and improving patient outcomes

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Given these inconsistencies, future research should focus on well-designed, large-scale RCTs that incorporate biomarker-guided stratification (e.g., SELENOP levels, GPx activity) to identify subgroups that would benefit most from selenium supplementation