PMDA refers to mutations as drivers when the degree of oncogene addiction is high and the drug efficacy can reasonably be predicted, by evaluating the results together with clinical studies at the early stage of development. PMDA Guideline The Philippine FDA released draft guidelines defining major and minor variations of medical and health-related devices throughout the lifecycle
Given that the neurological system harbors a significant abundance of PUFAs, ferroptosis induction may show promising efficacy in brain tumor treatment ( Curcumin, a polyphenol extracted from turmeric plants, upregulates ACSL4 expression and inhibits SLC7A11 and GPX4, leading to iron overload, GSH depletion, and lipid peroxidation, ultimately triggering ferroptosis in NSCLC cells (Tang et al., 2021)
Traditional hormonal avenues of treatment are also explored with repurposed medicines, like progestogens (two), GnRH antagonists (one) and other gynaecological medications such as fezolinetant, marketed for treatment of menopause related vasomotor symptoms (in Phase II), and three drugs initially developed for treating breast cancer (tamoxifen, raloxifene, letrozole)
PCOS patients have an increase in the oxidative stress with generation of excessive amounts of reactive oxygen species (ROS) and reduction of antioxidant capacity
Cell 171 , 628641.e26 (2017)
It turned out, that students who consumed a diet higher in sweets, desserts, and junk food, compared to students who consumed a diet high in fruits and vegetables, had a much higher risk for painful periods
