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Facts : X linked recessive disorder, MC in AA men G6PD enzyme involved in creating NADPH (cofactor required to create glutathione and prevent oxidation of hemoglobin) Without G6PD, hemoglobin becomes oxidized and denatures into Heinz bodies Variants are G6PD A- (moderate enzyme deficiency) and G6PD Mediterranean (severe enzyme deficiency History / PE : Fever Jaundice Abdominal pain Hematuria Diagnosis : Heinz bodies (denatured hemoglobin) and bite cells Positive Prussian blue staining (detects hemosiderin) G6PD levels are usually paradoxically normal during hemolytic episode Notes : Patients are less susceptible to malaria Associated With : Episodic hemolysis from fava beans , oxidant drugs (esp

NAD+ (Nicotinamide Adenine Dinucleotide) is a cofactor compound found in all living cells

Schedule II substances, such as Vyvanse, can be obtained only with a prescription from a licensed doctor and cannot be bought over the counter

PMID 35115649

In response to stress, p53 inhibits SLC7A11, resulting in release of ALOXE3 and decreased production and secretion of 12-hydroperoxyeicosatetraenoic acids, followed by induction of ferroptosis

BMC Gastroenterol.Garca-FernndezM.Castilla-CortzarI.Daz-SanchezM.NavarroI.PucheJ