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Biophysics 260, 601608

2.1.1.1) in the Parkinsonian brain

10.1242/dmm.047662 49 HofmannM

The compounds effects on NAD+ metabolism may have implications for muscle biology given the importance of NAD+-dependent enzymes in muscle function

The leap from animal model findings to confirmed human benefit is significant, and many compounds that show promise in preclinical research do not translate successfully to human medicine