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During this stage, mild symptoms might begin to appear, such as fatigue, dizziness, or poor concentration

Pan et al., 2019)

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As reported by the authors, administration of 50 mg/kg/alternate day of curcumin in conjuction with Al 3+ (100 mg/kg/day) for a period of 8 weeks significantly normalized the altered activities of mitochondrial complexes and reduced the levels of glutathione in rat brain