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Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma

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Bolaman Z, Kadikoylu G, Yukselen V, et al

They exhibit both oxidase and peroxidase-like catalytic activity

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They selectively block the serotonin transporter (SERT), thereby inhibiting the reuptake of serotonin at the synaptic cleft and increasing serotonergic neurotransmission ( In addition to reuptake inhibition, SSRIs differ in their pharmacokinetic properties, including half-life, hepatic metabolism, and interactions with cytochrome P450 enzymes