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The total of four conversions of NAD + to NADH in the joint glutamate synthesis/oxidation process suggested [two in astrocytes during the production of -ketoglutarate and one during glutamate oxidation (Figure 3B), together with one in neurons (Figure 5)] may explain the close to 1:1 ratio between rates of glucose oxidation and of glutamine/glutamate (GABA) cycle flux

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oxygen radicals can cause cell mutations, and Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase are scavengers of free radicals and reactive oxygen species in the body while protecting the membrane system of cells from damage and preventing cell carcinogenesis

Moreover, blending the extracts with the known anticancer drug 5-fluoruoracil boosted cell cytotoxicity

Organelle-associated therapeutic targeting of zinc dysregulation Zincs compartmentalized functions within cellular organelles highlight its potential relevance to therapeutic strategies