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July 2021

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We hypothesize that inhibiting intracellular glutamine transport via ASCT2, such as with V-9302, may be a more effective strategy for targeting glutamine metabolism in PIK3CA -mutant cancer cells than targeting downstream enzymatic activities, such as GLS1 or glutamine synthetase

Switching between brands may affect tolerability even with identical active ingredient concentrations

It is worth noting that the C-terminal leucine zipper motif is linked to c-MET with sufficient flexibility that is unlikely to impose the distance restraints between the two c-METs

In some cases, further work needs to happen to find and address the root cause(s) that are contributing to the condition, such as infections , traumatic stress, and toxins