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El desarrollo del feto depende totalmente del suministro de cido graso esencial proveniente del organismo materno, y una escasez de estos puede resultar en resultado adverso del embarazo

Otra consideracin importante es la posibilidad que el sildenafilo atraviesa la barrera placentaria afectando la hemodinmica fetal

It facilitates the transport of long-chain fatty acids into the mitochondria (the energy-producing parts of cells)

Similar shuttles have been proposed in peroxisomes or the endoplasmic reticulum (ER), but definitive demonstrations of their existence are still lacking (Tonazzi et al., 2006

However, valproic acid is one of the few medications with good evidence for treating seizures and behavioral symptoms in children with ASD with a good safety profile (4), so its mechanism and effect on the mitochondria are likely to be complex and dependent on age or stage of development

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