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Mice were started on intraperitoneal injection (ip) of copper-free GHK (Peptide Sciences, Henderson, NV ) at a dose of 7.5 mg/kg ( n = 8), or ip saline ( n = 12), twice daily for five days

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Currently, cellular senescence is understood as the response of cells to stress induced by both endogenous and exogenous factors, such as oncogenic factors, and genotoxic stress, telomere dysfunction, or mitochondrial degradation [11]

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(13) GHK is proposed to act as an endogenous antioxidant, potentially due to its selective targeting and neutralization of certain radicals, specifically hydroxyl (OH) and peroxyl (ROO) radicals

AICAR is itself a potent AMPK activator, the same intermediate compound that the pharmaceutical agent AICAR infusion uses to mimic exercise in rodent studies