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[PubMed: 6500232] Hall LN, Sanchez LR, Hubbard J, Lee H, Looby SE, Srinivasa S, et al

The cognitive load, the pace, the constant decision-making and the pressure of being "on" all day were simply too much

This mechanism may be primarily caused by the deregulation of the Ca 2+ homeostasis induced by the mutation in PSEN1 , as described in PSEN1 mutant AD iPSC-derived astrocytes (Oksanen et al., 2017)