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The robust stimulation of Nfe2l2 mRNA and Nrf2 protein levels by tanshinone IIA has been linked to hypomethylation of the Nfe2l2 promoter

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Eleven stopped after the initial blood draw (in two cases this was due to difficulty in collecting urine samples)

Damaged hepatocytes and other immune cells (e.g., Kupffer cells and neutrophils) release pathogenic endogenous molecules and danger-associated molecular patterns (DAMPs) that overactivate innate immune responses [43]

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This is a strategy where the whole comes out being greater than the sum of its parts. Li P, Butler A , Zhou Y., Magleby K, Gurnett C, Salkoff L