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Induction of ferroptosis by natural products in non-small cell lung cancer: a comprehensive systematic review

10.1007/s10863-015-9614-z 25 Ortiz-AvilaO.Smano-GarcaC

Certain retained components of various cell death pathways such as Fas (CD95)/Fas ligand (FasL, CD95L) signaling, caspase-3, caspase-8, or RIPK1/RIPK3 (receptor-interacting serine/threonine-protein kinase 3)/MLKL (mixed lineage kinase domain like pseudokinase) axis can be considered a heritage of the erythroid lineage cells

Nicotinamide Preservation 5-Amino-1MQ functions as a NAM-site competitive inhibitor, binding at the active site of NNMT and preventing the enzyme from methylating nicotinamide