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7.6 Integrative perspective and future outlook Taken together, both antioxidant-based and EV-based interventions face shared translational limitations rooted in model relevance, standardization, and clinical validation

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Membrane Disruption & Biofilm Inhibition AMPs work by inserting into and disrupting the lipid membranes of gram-negative bacteria including the key periodontal pathogens P

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Interestingly, we found that for Ccp5 / and Ccp1 / mice, the structural defects were observed mostly above the CC, whereas the tubulin shaft seemed preserved at the CC, as it has been described in mice mutant for the bulge protein LCA5 (Faber et al, 2023) (Fig

doi: 10.1186/s12943-024-02105-9 15 ZhaoYZhangBZhangQMaXFengH