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Intrinsic caspase-independent apoptosis is also suspected of being involved in neuronal death in PD

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

Important safety considerations include common adverse effects such as gastrointestinal symptoms (nausea, vomiting, diarrhea), which occur in 20-40% of patients but typically diminish with continued use

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