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Further, current data identified a cross-connection between altered Hcy levels and ocular diseases such as retinopathy, cataract, maculopathy, optic atrophy, pseudo-exfoliative glaucoma, and retinal vessel atherosclerosis [179]

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this approach is also serviceable for generating mutants containing - in addition to &/or in combination with the 20 naturally encoded polypeptide-forming alpha- amino acids - other rare &/or not naturally-encoded amino acids and amino acid derivatives