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Arthritis Rheum 40 , 226236 (1997)

Genetic and epigenetic alteration as an adaptive response to chemotherapy that majorly influences the drug resistance The study of hereditary phenotypic variations without change in the DNA sequence is referred to as "epigenetics" and was initially introduced by Conrad Waddington (1940), who linked this term with gene and gene products [72]

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For colorectal cancer, Yu et al