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What barrier for the BBB

Classic and Advanced Ceramics: From Fundamentals to Applications (Wiley, 2010)

10.1016/j.prmcm.2022.100135 105 LeeJ

Allergies et effets secondaires (rares) : Ractions allergiques la cyanocobalamine (rash cutan, dmangeaisons, trs rare) Douleur au point dinjection (injection IM) Acn passagre (rare, avec doses trs leves de B12) Vitamine B12 : retenir sur les dlais et les effets rels La vitamine B12 na pas deffet immdiat comparable un stimulant

Dose, route, timing, and model artifacts Preclinical doses (for example, T4 at 630 mg/kg in rats, or BPC-157 at microgram-to-nanogram-per-kilogram ranges) do not translate to humans by simple scaling, and route and timing strongly shaped the reported outcomes