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doi: 10.1089/ars.2012.4581 11 RobbinsRJ

AMPK and mTORC1 exist in a negative feedback loop [23], fine-tuning each others activity to carefully balance catabolic (mTORC1 inhibits , AMPK activates ) and anabolic (mTORC1 activates , AMPK inhibits ) cellular processes such as protein turnover (synthesis and degradation) and glucose and lipid metabolism