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The link between SARS-CoV-2 and Parkinsons disease PD COVID-19 can exacerbate PD symptoms, which indicates the neurotropic nature of COVID-19 infection, either directly by virus tropism and host neuronal cell lysis in the basal ganglia as well as indirectly via microglia activation, increased proinflammatory mediators production, with vascular injury in the stressful hypoxic brain [108]