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Since many members of the FAD/NAD-linked reductase family have similar catalytic mechanisms, the unique mechanism of inhibition identified in this study for TGR broadly opens new routes to selectively inhibit homologous enzymes of central importance in numerous diseases

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Drger, A., draeger-lab/ModelEditingTools: ModelEditingTools version 1.0.0initial Release, Zenodo , (2025)

Abbreviations used BBB blood brain barrier BBBD blood brain barrier disruption EAAC1 excitatory amino acid carrier type 1 GFAP glial fibrillary acidic protein GSH reduced glutathione GSSG oxidized glutathione HPLC-ECD high performance liquid chromatography with electrochemical detection Iba1 ionized calcium binding adaptor molecule 1 ICAL Immunocal MRI magnetic resonance imaging PBS-T phosphate-buffered saline with 0.1% Triton X-100 PHF paired helical filament PVDF polyvinylidene difluoride SDS-PAGE sodium dodecylsulfate polyacrylamide gel electrophoresis TBI traumatic brain injury Footnotes Conflicts of Interest The authors have received funding from Immunotec Inc