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At low intracellular concentrations (0.011 M), H 2 S injects electron equivalents into the mitochondrial electron transport chain (mETC) by reducing quinone to quinol via sulphide:quinone oxidoreductase (SQR), ultimately stimulating ATP production

This is a problem seen in preterm infants who are more susceptible to the effects of oxidant injury due to developmental deficits in antioxidants

The absorption of glutathione and other substances from the gastrointestinal tract 38 and oral mucosa 39 has been the subject of some studies and it is now well known that orally administered glutathione cannot be relied upon for therapeutic purposes

Joshi K, Chavan P, Warude D, Patwardhan B

Upon crossing the cell membrane, the NPs accumulate in mitochondria, enhancing local drug concentration