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Description

During these periods of oxidative stress, levels of GSSG may rise, prompting the induction of GGT to facilitate the recycling of precursor amino acids for GSH synthesis to maintain a balanced GSH-to-GSSG ratio [29,87]

doi: 10.1080/17461391.2013.785597

Xiaoyu Zhao: Investigation, Visualization

Glutathione treats the inside

No, not on that basis alone

In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels