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mTORC1 also regulates mTORC2 signaling, affecting multiple aspects such as cytoskeleton remodeling, cell proliferation and survival (137)

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The incorporation of pH-, enzyme-, or light-sensitive linkers enables controlled release of therapeutic cargo in specific microenvironments (e.g., acidic tumor regions), thereby improving targeting precision and therapeutic efficacy [86, 206]

489 Another statin, fluvastatin (NCT00416403), has measurable biological effects by reducing tumor proliferation and increasing apoptosis in breast cancer cells, with the effect being more pronounced in high-grade tumors