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While our in vitro experiments and cell studies provide robust support that Irisin influences lactate metabolism and mitochondrial function by modulating the SIRT1/HIF-1/PGC-1 axis, data from further validation using specific inhibitors such as EX-527 in vivo are still lacking

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The eight-week clinical trial on children aged 3 to 13 used oral or transdermal applications of Glutathione