glutathione deficiency paracetamol Glucuronide - an overview Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Most people don't realise this Paracetamol breaks down into a toxic compound called NAPQI. Your liver neutralizes it using glutathione (your body's defense shield). But when you take it too often Solved The following figure shows the metabolism of the Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione depletion biomarkers ophthalmic acid and 5 oxoproline in humans and rats Integrative Biology (RSC Mind the Anion Gap: 5 Oxoproline Induced High Anion Gap Metabolic Acidosis in End Stage Renal Disease Cureus glutathione deficiency paracetamol Divergent effects of depletion on isocitrate dehydrogenase 1 and the pentose phosphate pathway in hamster liver Jin 2020 Physiological Reports Full article: Paracetamol ( acetaminophen) overdose

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