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Hence, the development of an efficient drug delivery system has the potential to facilitate a continuous and regulated release of therapeutic substances, thereby fostering recovery from the secondary damage to the brain following TBI (Mohammed et al., 2023)

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This classification scheme has been under-way amended and refined into seven classes, six of which include soluble (cytoplasmic) proteins and one microsomal proteins [11, 12]

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Changes in intestinal flora can lead to TJ disruption and increased intestinal permeability