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Others, such as corynoxine, target upstream phosphatases such as protein phosphatase 2A to dually inhibit AKT signaling (98), whereas Gboxin and its analog Y9 trigger lysosomal dysfunction and autophagic impairment (99)

Inhibitors of GLS, GDH, GCPII, GTK, or other key enzymes could be used in combination with standard chemotherapy treatments to increase their overall effectiveness (Fig