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(PubMed) Kauwell GP, Wilsky CE, Cerda JJ, et al

Silencing p53 significantly alleviated PMB-induced iron accumulation and lipid peroxidation, increased the expression of TFR1 and ALOX12, and decreased the expression of GPX4 and SLC7A11 [178]

J., Hegeds, L

doi:10.1155/2018/5749120

EMBO J (2017) 36(3):2529

Upon release into the circulation, these cytokines exert diverse effects on various tissues, such as the brain, muscle, and adipose tissues, leading to appetite suppression, suppression of muscular protein production, and promotion of lipolysis, which ultimately lead to the progression of cachexia