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doi: 10.1111/j.1755-3768.2012.02384.x 152 ZigmanSSchultzJYuloT

1 Introduction Aging manifests in multiple systems throughout the entire body

In patients with impaired glucose tolerance and DPN, the staining patterns of sural nerves were similar but less intense compared with those found in patients with overt diabetes, indicating that ROS production and proinflammatory pathways are activated even before chronic hyperglycemia occurs [42]