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Lin X, Zamora PO, Albright S, Glass JD, Pea LA

It is an analogue of the ACTH(4-10) fragment of adrenocorticotropic hormone, specifically derived from the ACTH(4-7) core sequence (Met-Glu-His-Phe) the minimal active fragment responsible for the cognitive and neuroprotective activity of ACTH with a C-terminal Pro-Gly-Pro (PGP) tripeptide extension appended to enhance metabolic stability and, as subsequent research has revealed, to contribute independent pharmacological activity of its own

A common approach is to add 1 to 2 mL of bacteriostatic water to a vial containing 5 mg of peptide, yielding a concentration of 2500 to 5000 micrograms per mL

Media replacement schedules vary based on system design and operational parameters but are typically required every 25 years for most BAC systems

2009;60(Suppl 7):191-196

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