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Cytotoxic biscembranoids from the soft coral Sarcophyton pauciplicatum

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[] Cellular mechanism of induced cell death consists of the activated tumor protein 53, that is, p53, phosphorylation at activator protein, that is, AP-1, which collectively lead to cell division arrest by stimulating p 21 , downregulating cyclins and cyclin dependent kinases

Recent studies demonstrated that individuals with glutathione transferase omega polymorphisms, genotype variants GSTO1*AA (rs4925) and GSTO2*GG (rs156697), showed significant propensity towards development of clinical manifestations in COVID-19 supporting the significance of these enzymes in the regulation of redox homeostasis and immune response, especially NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation (Zhao and Zhao, 2020

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Mechanisms of l-cysteine neurotoxicity