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18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms

[DOI] [PubMed] [Google Scholar] 57.Zhang P., Li T., Wu X., Nice E.C., Huang C., Zhang Y

Biochemistry 38(34):1107911085 Li M, Ma D, Qiao J, Cheng Z, Wang Q, Zhou Z (2024) Han L (2019) Development of high-performance nitrile hydratase whole-cell catalyst by automated structure-and sequence-based design and mechanism insights

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When alkaline water is consumed, it passes through the highly acidic stomach environment before absorption, which neutralises much of its alkalinity