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Conversely, reducing ROS using catalase enhanced RUNX2 stability and promoted osteoblast differentiation and bone formation when GSH biosynthesis was limited

Since many pathologic and toxic conditions can lead to activation of CMK and phosphorylation of GCLC, inhibition of GCL may further contribute to toxicity

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The folding of polypeptides into their functional forms is the topic of the next section.

The modulation in the expression and redundancy of GSTs ascertain its enigmatic roles in plant growth and development