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All three running trials were completed between 0600 and 0900 to avoid circadian effects on performance (Table 1

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Their lipid-peroxidation-induced mtROS activate PKR-like endoplasmic reticulum kinase (PERK) signalling, whereas NF-B drives IL-1 and IL-6 transcription

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Elevated tumor expression of the core autophagy gene ATG16L1 is associated with suboptimal clinical response to anti-PD-L1 treatment in KRAS-mutant tumors in the IMblaze370 (NCT02788279) phase III clinical study of atezolizumab for advanced metastatic MSS-CRC