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These effects mirror what has been seen with GLP-1 therapies but are often less intense when appropriate titration protocols are followed

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Risk of cardiovascular disease in relation to the use of combined postmenopausal hormone therapy: detection bias and resolution of discrepant findings in two Womens Health Initiative studies

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KEY POINTS Reactive Oxygen Species (ROS) are highly reactive substances derived from oxygen that are capable of damaging DNA, lipids and proteins

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Its cellular expression is controlled at the transcriptional level by nuclear factor (erythroid-derived 2)-related factor 2 (NRF2) (52), and at the post-transcriptional level, through degradation and deadenylation/polyadenylation processes (53)

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