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It can be either chronic or acute and may vary widely in severity

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a Hersbach, H., Bell, B., Berrisford, P., Biavati, G., Hornyi, A., Muoz Sabater, J., Nicolas, J., Peubey, C., Radu, R., Rozum, I., Schepers, D., Simmons, A., Soci, C., Dee, D., and Thpaut, J.-N.: ERA5 hourly data on single levels from 1940 to present, Climate Data Store [data set], 2023b

Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults